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Recommended high-yield glutathione production process for synthetic biological products

   2024-01-11 biopharmapi.comGSHWORLD1120
Brief:What is glutathione?Glutathione (r-glutamyl cysteine+glycine, GSH) is a type of substance that contains γ- A tripeptide

Recommended high-yield glutathione production process for synthetic biological products

What is Glutathione?

Glutathione (r-glutamyl cysteine+glycine, GSH) is a type of substance that contains γ- A tripeptide with amide bonds and thiol groups, composed of glutamic acid, cysteine, and glycine, exists in almost every cell of the body.

Glutathione can help maintain normal immune system function and has antioxidant and integrated detoxification effects.

The thiol group on cysteine is its active group (often abbreviated as G-SH), which can easily bind with certain drugs, toxins, etc., giving it an integrated detoxification effect.

Glutathione can not only be used in medicine, but also as a base material for functional foods, widely used in functional foods such as delaying aging, enhancing immunity, and anti-tumor effects.

Glutathione has two forms: reduced form (G-SH) and oxidized form (G-S-S-G), with reduced form glutathione accounting for the vast majority under physiological conditions.

Glutathione reductase can catalyze tautomerism between two types, and its coenzyme can also provide NADPH for pentose phosphate pathway metabolism

Market Size

QY data shows that the global glutathione market size in 2021 was approximately RMB 930 million, and it is expected to reach RMB 1.6 billion in 2028. The compound annual growth rate (CAGR) for the period from 2022 to 2028 is 6.9%.

In the coming years, there will be great uncertainty in this industry. The forecast data for 2022-2028 in this article is based on the historical development of the past few years, the opinions of industry experts, and the views of the analysts in this article.

glutathione

The core global manufacturers of glutathione include GSH Bio-Tech Co., Ltd., Kyowa Hakko Bio, and Morning Glory Biopharmaceuticals.

The top three manufacturers account for approximately 79% of the global market share.

China is the largest production region with approximately 63% of the market share, followed by Japan and Europe with 31% and 5% respectively.

The Asia Pacific region is the largest market with approximately 60% market share, followed by North America and Europe with approximately 28% and 11% market share, respectively.

In terms of product type, reduced glutathione (GSH) is the largest subdivision, accounting for approximately 78% of the market share. At the same time, in terms of application, pharmaceuticals are the largest downstream field, accounting for approximately 50%.

TECHNICAL INDEX

  • Production method: direct fermentation method

  • Fermentation cycle: 45h

  • Fermentation yield: 6-7g/L

  • Total cost 300/kg

 
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