Research on NMN Anti-Aging
On April 27, 2024, Professor Qu Lefeng, the first person in China specializing in vascular surgery and the first postdoctoral fellow in the field of vascular surgery in China, released the country's first anti-aging NMN human double-blind, randomized controlled clinical trial conducted in a tertiary hospital at the Lezhen Vascular Forum and the Spring Academic Forum of the Vascular Medicine Committee of the Chinese Society of Pathophysiology.
The experiment conducted a randomized, double-blind controlled trial on people before and after taking NMN to analyze the impact of NMN on human aging markers and record the regulation of transcriptional levels of genes related to aging, cell cycle, and diseases.
The test results show that after the subjects took NMN (300mg/ day) for 60 days, the levels of downstream aging-related metabolites of NMN in their blood significantly increased, and their physiological age significantly decreased!
Research on NMN Extending Lifespan of Premature Aging Mice
In March 2024, a research team from Wenzhou Medical University in China published a study in the journal Food & Function, which showed that:
NMN can significantly extend the lifespan of mice and improve their aging phenotypes, including weight gain and overall health. month
To delve deeper into the principles of aging and discover effective anti-aging strategies, researchers selected 5 - to 7-week-old Zmpste24−/− mice (a model of premature aging) and administered them orally with different doses of NMN (100 or 300 mg/kg).
It was found that compared with the control group, the overall lifespan of mice in the group receiving a dose of 300 mg/kg of NMN (N300 group) was prolonged, that is, the average lifespan was extended by approximately 14%.
Moreover, the median life expectancy also increased by approximately 20%, and the maximum lifespan of mice also extended by about 10%.
It is also worth noting that compared with the control group, the weight gain of mice in the N300 group was more significant in the sixth and eighth weeks.
In conclusion, NMN not only extends their lifespan but also improves their quality of life.
NMN can prevent physical decline and improve sleep
In May 2024, a clinical trial published by a Japanese research team in Geroscience found that taking NMN can prevent physical decline and improve sleep quality.
In the experiment, the elderly group in the experimental group that took 250mg of NMN daily for 12 consecutive weeks showed significant progress in multiple dimensions such as walking speed and grip strength.
It is particularly worth mentioning that in the key indicator of walking ability assessment - the 4-meter walk test, the elderly in the NMN group demonstrated a more rapid walking time compared to the placebo control group.
This positive outcome suggests that the intake of NMN may effectively help the elderly maintain or even increase their walking speed, thereby having a positive impact on their daily self-care ability and independence.
The NMN experimental group showed significant improvement in the Pittsburgh Sleep Quality Index (PSQI) score, especially in the "daytime dysfunction" and "overall PSQI" scores, which were significantly lower than those of the placebo group.
Research on NMN Improving Ovarian Health
A team led by Professor Chen Rong from Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, and a team led by Professor Zhang Peng from Beijing Children's Hospital, Capital Medical University, jointly discovered that short-term NMN treatment could significantly increase the NAD+ level in the ovaries of aging mice and the ovaries to body weight ratio, and inhibit ovarian atrophy.
By further exploring the impact and mechanism of NMN on ovarian aging, researchers found that NMN could improve the serum hormone levels and antioxidant factors of aging mice, while reducing the expression of pro-inflammatory factors, and the number of aging mice increased significantly.
The results of scanning electron microscopy showed that NMN treatment altered the morphology and distribution of lipid droplets and mitochondria within granular cells, revealing its potential mechanism of action.
Transcriptome sequencing and subsequent verification experiments have shown that the positive effects of NMN on aging ovaries are achieved by enhancing mitochondrial function, improving energy metabolism, and reducing inflammation levels.
