Insomnia is a common sleep disorder, with approximately 30% of the global population suffering from some degree of insomnia.
01. Adjust your body clock
The body clock is crucial for regulating the sleep-wake cycle.
NMN can affect the expression and regulation of clock genes by increasing the level of NAD+ in the body.
NAD+ is involved in a variety of metabolic processes in cells and is an important coenzyme of SIRT1 and other deacetylases.
SIRT1 can deacetylate circadian clock proteins, regulate the rhythm of the circadian clock, make it more stable and regular, and then help adjust the sleep cycle, so that the time of falling asleep and waking up more in line with the natural physiological rhythm.
02. Promote neurotransmitter balance
Neurotransmitters such as gamma-aminobutyric acid (GABA) and serotonin play a key role in regulating sleep.
NMN may support the normal function of nerve cells by improving cell metabolism and energy levels, and help maintain the synthesis, release and metabolic balance of neurotransmitters.
For example, it may promote the synthesis of GABA or enhance the function of its receptors, which is an inhibitory neurotransmitter that relaxes the nervous system and reduces the excitability of neural activity, thereby inducing the body to enter a relaxed state that facilitates falling asleep and maintaining sleep.
03. Reduces oxidative stress and inflammation
Oxidative stress and inflammation are closely associated with decreased sleep quality.
NMN has antioxidant effects, which can reduce the level of oxidative stress in cells, reduce the production of free radicals and damage to cells.
At the same time, it can inhibit the inflammatory signaling pathway and reduce the expression and release of inflammatory factors.
When the body is in a state of low oxidative stress and low inflammation, the nervous system and various organs of the body are better able to rest and recover, and the quality of sleep will be correspondingly improved, as shown by fewer night-time awakenings and deeper sleep.
04. Improve mitochondrial function
During sleep, the body's cells need to carry out activities such as energy storage and metabolic waste removal, which depend on good mitochondrial function.
NMN can increase the level of intracellular NAD+, activate genes and signaling pathways related to mitochondrial function, promote mitochondrial biosynthesis and functional repair, and improve the energy production efficiency of cells.
Adequate energy supply helps to maintain the normal physiological function of the body during sleep, ensure the depth and quality of sleep, and make people feel more energetic after waking up.
