NMN (nicotinamide mononucleotide) was once known as a "longevity molecule", and its mechanism of delaying aging by increasing NAD+ levels is highly sought after.
"With the rise of mRNA gene coding technology, especially for the improvement of skin aging, this technology not only bypassing the limitations of traditional ingredients, but also through direct intervention in gene expression, achieving a breakthrough in anti-aging from the root."
From the three dimensions of mechanism, effect and safety, explain why mRNA technology has comprehensively surpassed NMN and become a new benchmark for anti-aging skin care
Mechanism: NMN "Curve to save the Nation" vs mRNA "precision strike"
1. Anti-aging logic of NMN
By supplementing the precursor of NAD+ (Coenzyme I), NMN indirectly improves the energy metabolism and DNA repair ability of cells.
With age, the efficiency of NAD+ synthesis decreases significantly due to accumulation of DNA damage and aging of cellular pathways.
Supplementing NMN can improve cell metabolism to a certain extent, so oral NMN is regarded as one of the effective anti-aging ingredients.
However, the action path of NMN is long and depends on the function of cells themselves, which cannot solve the fundamental problem of cell aging. It is even more difficult to improve the skin condition through skin application, and it has no direct promotion effect on the synthesis of key substances such as collagen.
NMN needs to undergo multi-step transformation to play a role, and each metabolic pathway may be affected by various internal and external factors to varying degrees, so it cannot ensure that it can accurately play a role in skin collagen regeneration.
2. Revolutionary breakthrough of mRNA technology
mRNA (messenger ribonucleic acid) is a single-stranded RNA molecule that carries genetic information from DNA to the cytoplasm and directs protein synthesis.
The Central Dogma of Molecular Biology The central dogma of Molecular Biology
In the nucleus, mRNA is generated by transcription using DNA as a template, and its nucleotide sequence is complementary to DNA.
After entering the cytoplasm, the ribosome reads the codon on the mRNA and synthesizes the polypeptide chain according to the principle of one amino acid for every three base pairs.
The final synthesis of various proteins and signaling substances.
In the field of skin care, through long-term self-developed CGSMR technology, Zieyan brand directly transmits "young instructions" to cells through mRNA, skipping complex signal pathways and accurately guiding the synthesis of key substances such as collagen.
For the first time, humans can "command" cells to produce what they need at will
mRNA technology directly drives collagen production (Encoding mRNA sequence for collagen synthesis - assembly of CGSMR active factors containing mRNA - facial use/introduction - targeted delivery of mRNA into cells - mRNA guiding collagen synthesis)
Effect: Data reveals' dimensionality hit '
1. Cell experiment
In cell experiments, NMN can increase the activity of Sirtuins longevity genes by 50%, thereby prolonging the cell life cycle, increasing the level of NAD+, inhibiting inflammation, and clearing more than 90% of free radicals.
It was proved that NMN could improve the living state of cells, prolong cell life and delay senescence.
In cell experiments, the mRNA produced by CGSMR technology can quickly generate collagen 6,000 times the quality of mRNA itself, which greatly improves various skin aging problems caused by collagen loss.
Proof: mRNA does not have any mother-in-law "overall improvement", belongs to the direct, direct attack on the root of the problem technology, said to solve the problem of collagen deficiency, to solve the problem of collagen deficiency, the other will not affect.
2. Human experimentation
NMN's record in the cosmetic raw material system of the Domestic Food and Drug Administration is moisturizing.
The anti-aging effect of NMN is mainly that NMN improves cell health by increasing cell NAD+, thus increasing the expression of collagen.
Due to the long path and the influence of various factors, there is no quantitative clinical trial data to illustrate the anti-aging effect of NMN on the skin.
Future trend: mRNA technology opens the era of anti-aging skin 2.0
1. Limitations of NMN
NMN essentially promotes the physiological function of cells by improving energy metabolism
It could, in theory, "encourage cells to make collagen."
However, they are limited by the aging of the cells themselves and cannot solve core problems such as faulty gene expression
2. The limitless potential of mRNA
mRNA technology is a platform technology field
In the future, it can be customized to solve multiple problems such as skin color, severe aging, and damage repair
Even customized with their own gene sequencing to achieve "gene-level precision anti-aging"
Literature citations:
1. Imai, S. et al. (2000). NAD+ biosynthesis and its role in the regulation of circadian rhythms. Nature, 408(6813), 860-864.
2. Karikó, K. et al. (2005). Suppression of RNA recognition by Toll-like receptors: The impact of nucleoside modification and the evolutionary origin of RNA. Immunity, 23(2), 165-175.
3. Zhang, H. et al. (2016). NAD+ repletion improves mitochondrial and stem cell function and enhances lifespan in mice. Science, 352(6292), 1436-1443.
4. Yoshino, J. et al. (2011). Nicotinamide Mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell metabolism, 14(4), 528-536.
