As far as the raw materials themselves are concerned, for one thing, these so-called raw materials are likely to be shoddy or impersonated with other ingredients;
Second, even if it is real NMN raw materials, eating it directly is also a huge risk.
At present, there are four kinds of extraction processes of NMN raw materials: chemical synthesis, fermentation, biological enzyme method, enzyme directed evolution technology and the combination of biological enzyme method.
The advantages and disadvantages of NMN extraction technology are mainly measured in the following three points:
First, whether it is safe without chemical residue;
Second, whether the purity of NMN is high enough;
Third, whether the content of β-NMN is high enough
Yeast method:
The yeast was cultured in a medium containing niacin and fermented to produce NMN. Then, NMN was extracted from the fermentation liquid by centrifugation, filtration and other steps. Yeast is rich in NAD+, which is isomer with NAD+ in human body, so it is a common method to extract NMN from yeast.
Chemical synthesis method:
NMN was synthesized from raw materials by various chemical reactions. Although the method can obtain high-purity NMN, the cost is high, and chemical impurities may be produced in the production process, which is a potential threat to human health.
Biological enzyme catalytic method:
This method is equivalent to imitating the working process of the catalytic enzyme in human body and directly synthesizing NMN in vitro. It is currently the industry's leading technology, green, non-toxic and harmless.
The NMN extracted by this method has high purity, is easy to be effectively converted into NAD+ in the body, and is easily absorbed by the body.
Biological enzyme synthesis + enzyme directed evolution technology, the fourth generation extraction technology is based on the biological enzyme method, the application of enzyme directed evolution technology.
American scientist Frances H. Arnoid has won the 2018 Nobel Prize in Chemistry for her enzymatic directed evolution technique. The activity and specificity of the enzyme are greatly improved and safer.
Possible problems caused by eating NMN raw materials directly
Problem 1: Chemical residue
Chemical residue is indeed a possible problem in the production of NMN raw materials by chemical synthesis. Due to the low cost of chemical synthesis, some manufacturers may choose this method to produce NMN raw materials, but this can lead to residual harmful chemicals in the raw materials.
These chemical residues may pose potential health risks, such as allergic reactions and chronic toxicity that may result from long-term ingestion.
Problem 2: Raw material contamination
There is indeed a risk of microbial contamination in the storage, packaging and transportation of raw materials. If raw materials are not properly handled and secured during these processes, microbial contamination can result, increasing the health and safety risks of the product.
Therefore, regular NMN products will be strictly tested before leaving the factory to ensure that the purity of raw materials, the amount of addition meets the quality standards, and check whether microorganisms, heavy metals, etc., meet the safety standards.
When purchasing NMN products, consumers should choose formal channels to purchase, and pay attention to the inspection report and certification information of the product.
Problem 3: Limited effect
Even NMN raw materials processed by mainstream technologies may have limited effects. This may be because the process of converting NMN into NAD+ in the body requires the synergistic action of other factors.
